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我们用~(51)铬释放法检测了61例肾虚患者外周血 NK 细胞活性,发现肾虚患者的 NK 细胞活性明显低于健康人(P<0.001);且肾阳虚组低于肾气虚组(P<0.01)和肾阴虚组(P<0.01),而肾气虚组与肾阴虚组对比 P>0.05。结果表明 NK 细胞活性低下是多病种肾虚的共同表现之一。同时还发现43例肾虚患者的血浆能强烈抑制健康人的NK 细胞活性,说明肾虚患者血浆中存在某些能强烈抑制 NK 细胞活性的物质。提示我们应进一步研究中医肾与 NK 细胞的关系及补肾治疗对 NK 细胞活性的增强和调节作用。
We detected the activity of NK cells in peripheral blood of 61 patients with kidney deficiency by ~(51) chromium release method and found that the activity of NK cells in patients with kidney deficiency was significantly lower than that in healthy individuals (P<0.001); and the kidney-yang deficiency group was lower than Shenqi-deficiency group ( P<0.01) and Shenyin deficiency group (P<0.01), while Shenqi deficiency group and Kidney-yin deficiency group had P>0.05. The results indicate that the low activity of NK cells is one of the common manifestations of multi-disease kidney deficiency. At the same time, it was also found that the plasma of 43 patients with kidney deficiency can strongly inhibit the activity of NK cells in healthy people, indicating that there are certain substances in the kidney deficiency patients that can strongly inhibit the activity of NK cells. It is suggested that we should further study the relationship between TCM kidneys and NK cells and the effect of kidney-tonifying treatment on the activity of NK cells.