米索前列醇,一种前列腺素E的合成类似物,在巴西及美洲中、南部的一些国家常被用于人工流产。此药并不能十分有效地终止妊娠且会造成胎儿畸形。作者对此进行了研究。1992年5月～1997年4月间,选自巴西·圣保罗的42例婴儿为研究对象,他们的母亲在妊娠头3月均服用过米索前列醇且婴儿出生后均为先天畸形,作者对每位母亲服用米索前列醇的情况及用药剂量进行了调查,并由遗传学家或神经儿科学家对婴儿进行了体检。结果发现:17例婴儿有马蹄内翻足且伴有颅神经缺损;10例婴儿有马蹄内翻足及严重的关节弯曲。最为突出的表现是关节弯曲局限于下肢(5例)及肢端缺损(9例)伴有或不伴有默比厄斯氏征(Mbius)。这些妇女服用米索前列醇的常用剂量为800(200～16000)μg。 结果表明:由于米索前列醇能引起子宫收缩造 Misoprostol, a synthetic analogue of prostaglandin E, is commonly used in abortion in some countries in the south in Brazil and the Americas. This medicine does not terminate the pregnancy very effectively and can cause fetal malformations. The author studied this. From May 1992 to April 1997, 42 infants selected from Sao Paulo, Brazil, whose mothers were treated with misoprostol in the first trimester of pregnancy and whose infants were born with congenital malformations, Each mother was surveyed on misoprostol and dosing, and the baby was examined by a geneticist or neurosynchronist. The results showed that: 17 infants had clubfoot with cranial nerve defect; 10 infants had clubfoot and severe joint flexion. The most prominent manifestation is the limited flexion of the joint with lower extremity (5 cases) and amputation (9 cases) with or without Mbius. The usual dose of misoprostol for these women is 800 (200-16000) μg. The results show that: due to misoprostol can cause uterine contractions