雄性成熟大白鼠经口喂雷公藤单体＆＿４５０μｇ／ｋｇ／日，每周６天，６周后断头处死，采用电子显微镜观察睾丸曲细精管内和附睾内的精子，结果显示Ｔ＿４影响曲细精管内精子形成过程，经过附睾后精子损伤加重。微管与微丝的结构和功能的破坏是导致精子畸形的主要原因，精子膜结构对Ｔ＿４作用也非常敏感。 Mature male rats were orally fed with Tripterygium wilfordii monomer & _450μg / kg / day, 6 days a week, 6 weeks after decapitation and electron microscopy of testicular seminiferous tubules and sperm within the epididymis, the results show T_4 affect the curvature Spermatogenesis in spermatogenesis, post-epididymal sperm injury worsened. The destruction of the structure and function of microtubules and microfilaments is the main reason for the deformity of sperm. The structure of sperm membrane is also very sensitive to the action of T_4.