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本文报告11例肌紧张异常,其中5例有阳性病史,而且2例经CT证实底节存有病灶,考虑为症状性肌紧张异常。余6例皆无阳性病史,而且4例经CT检查,皆为阴性,故认为系原发性肌紧张异常。此病的特殊临床表现为主动肌与对抗肌的持续收缩而造成不自主运动及异常姿势,不自主运动一般较慢,异常姿势往往为扭转形式。但要确定为症状性抑或原发性,则需做许多检查,两组的预后可能不同,但治疗则相似:药物和立体定向的外科手术有一定的疗效。若为局部型或节段型尚可应用感觉反馈治疗。这些疗法都不能满意。近来在原发性肌紧张异常患者的血浆中发现β-多巴胺羟化酶(DβH)的升高,将来也可能发现更多的神经介质的不平衡,对治疗上可出现新情况。
This article reports 11 cases of muscle tension abnormalities, of which 5 cases have a positive history, and 2 cases confirmed by the end of the CT-lesion lesions, considered as symptomatic muscle tension abnormalities. The remaining 6 cases had no history of positive disease, and 4 cases by CT examination, all negative, so that the department of primary muscle abnormalities. The special clinical manifestations of this disease are the persistent contractions of the active muscle and the antagonistic muscle resulting in involuntary movements and abnormal postures. The involuntary movements are generally slow, and the abnormal postures are often in the form of reversals. However, to determine whether symptomatic or primary, you need to do a lot of tests, the prognosis of the two groups may be different, but the treatment is similar: drugs and stereotactic surgery have a certain effect. If the partial or segmental type can still apply sensory feedback treatment. None of these therapies are satisfactory. Recently in patients with primary muscle abnormalities in the plasma found in β-dopamine hydroxylase (DβH) increased in the future may also find more imbalance of neural mediators, the treatment of new situations may arise.