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采用ＨＢｓＡｇ 分别刺激体外培养的正常肝细胞及肝癌细胞，观察培养液中ＮＯ－２ ／ＮＯ－３ ，以及ＮＯ 对这两种细胞ＤＮＡ合成的影响。结果发现：ＨＢｓＡｇ 可以诱导正常肝细胞及肝癌细胞产生ＮＯ，并抑制这两种细胞ＤＮＡ合成，但以正常肝细胞受抑较严重。提示：乙肝病毒及乙肝病毒表面抗原也是引起肝硬化病人ＮＯ水平增高的重要原因。ＮＯ可能是肝硬化组织易于癌变的可疑诱因。
HBsAg was used to stimulate normal hepatocytes and hepatoma cells cultured in vitro, and NO-2/NO-3 in culture medium was observed, as well as the effect of NO on DNA synthesis of both cells. The results showed that: HBsAg can induce normal hepatocytes and hepatoma cells to produce NO, and inhibit the DNA synthesis of these two cells, but normal liver cells are more severely suppressed. Tip: Hepatitis B virus and hepatitis B virus surface antigen are also important causes of elevated NO levels in patients with cirrhosis. NO may be a suspected cause of cirrhotic tissue prone to canceration.