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目的 研究分析肝细胞腺瘤临床病理学特征有助于提高临床诊治水平。方法 复阅所有病例临床病理资料,AFP、PCNA、P53蛋白检测采用免疫组化ABC法。结果 本组患者男性4例,女性5例,年龄20—58岁(平均34.5岁),肿瘤直径3.2—16.5cm(平均11.4cm),MRI提示肝脏有等高信号占位性病变,组织病理形态学呈良性改变,AFP、PCNA、P53蛋白染色均为阴性。结论 肝细胞腺瘤术前易误诊为原发性肝癌或海绵状血管瘤,如就诊患者为年轻女性,有或无腹痛,实验室检查指标正常,影像学提示肝脏占位性病变,临床应考虑肝细胞腺瘤的诊断,必要时行肝穿刺活检。
Objective To study and analyze the clinicopathological features of hepatocellular adenomas to help improve clinical diagnosis and treatment. Methods The clinical and pathological data of all cases were reviewed. AFP, PCNA and P53 protein were detected by immunohistochemical ABC method. Results There were 4 males and 5 females in this group, aged 20-58 years (average 34.5 years old), tumor diameter 3.2-16.5cm (mean 11.4cm), MRI suggested that the liver had isotopic signal occupying lesions, histopathological morphology The study was benign, and the staining for AFP, PCNA, and P53 were negative. Conclusion Hepatocellular adenomas are often misdiagnosed as primary liver cancer or cavernous hemangiomas before operation. If the patient is a young woman with or without abdominal pain, the laboratory examination index is normal. The imaging findings suggest hepatic space occupying lesions. Clinical considerations should be considered. Diagnosis of hepatocellular adenoma, liver biopsy if necessary.