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目的:探讨食管鳞癌组织中神经纤维的分布情况。方法:应用免疫组化ABC法,探查手术切除的食管鳞癌组织里S100及GAP-43阳性神经纤维的分布情况,并分析其与患者临床病理参数的关系。结果:相对于正常组织,食管鳞癌组织中存在相当数量的S100及GAP-43阳性神经纤维(束)不规则地分布于肿瘤细胞之间,且S100阳性纤维密度大于GAP-43阳性纤维密度;统计分析显示肿瘤组织中纤维密度与患者的肿瘤大小、淋巴结转移相关。结论:食管鳞癌组织中确实存在神经纤维分布,并对肿瘤发展起一定作用。
Objective: To investigate the distribution of nerve fibers in esophageal squamous cell carcinoma. Methods: Immunohistochemical ABC method was used to investigate the distribution of S100 and GAP-43 positive nerve fibers in esophageal squamous cell carcinoma and its relationship with clinicopathological parameters. Results: Compared with normal tissues, a significant number of S100 and GAP-43 positive nerve fibers (bundles) in esophageal squamous cell carcinoma were irregularly distributed among tumor cells, and S100 positive fibers density was higher than that of GAP-43 positive fibers. Statistical analysis showed that the fiber density in tumor tissue correlated with tumor size and lymph node metastasis. Conclusion: There is indeed a distribution of nerve fibers in esophageal squamous cell carcinoma and play a role in tumor development.