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近年来的研究表明,自分泌产生的肽类生长因子对细胞增殖分化的调控紊乱是细胞恶变的可能机制之一。碱性成纤维细胞生长因子(bFGF)具有多种生物学活性,包括影响血管生长、伤口修复、组织再生、胚胎发育和分化、内分泌调节以及具有神经营养作用等。恶性胶质瘤C6细胞系能产生bFGF,表达高亲和性bFGF受体,且bFGF受体的表达水平与肿瘤的恶性程度相关。为了探讨bFGF在胶质瘤恶变中的调控作用,本文作者将牛bFGF基因转染C6细胞,并观察了其体外生长状况。
In recent years, studies have shown that the autocrine production of peptide growth factor on the regulation of cell proliferation and differentiation disorder is one of the possible mechanisms of cell malignant. Basic fibroblast growth factor (bFGF) has a variety of biological activities, including affecting blood vessel growth, wound repair, tissue regeneration, embryonic development and differentiation, endocrine regulation and neurotrophic effects. The glioblastoma C6 cell line produces bFGF, which expresses a high-affinity bFGF receptor, and the expression level of bFGF receptor correlates with the malignancy of the tumor. In order to investigate the role of bFGF in the regulation of malignant glioma, we transfected bFGF into C6 cells and observed its growth in vitro.