恶性肿瘤的生长和转移与肿瘤区域的血管密切相关,肿瘤区域的新生毛细血管是肿瘤赖以生长和生存的物质基础,肿瘤细胞需要新生血管为迅速生长的肿瘤提供营养物质和排出废物。早在七十年代初就有人提出把抑制肿瘤血管形成作为肿瘤治疗的一种途径,以后这种以肿瘤血管为靶标的治疗策 The growth and metastasis of malignant tumors are closely related to the blood vessels in the tumor area. The nascent capillaries in the tumor area are the material basis for the growth and survival of the tumor. Neoplastic cells need neovascularization to provide nutrients and waste for the rapidly growing tumor. As early as the early 1970s, it was suggested that inhibition of tumor angiogenesis as a means of tumor treatment, after which the treatment of tumor blood vessels as the target