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近年来高危新生儿全身性霉菌感染,特别是念球菌血症的发生率增高,全身霉菌感染的低出生体重儿的病死率高达54%。为了解其发病的高危因素,作者分析了20例曾住入新生儿监护室(NICU)的现年龄4个月以内的念珠菌血症病例,并以同期住入新生儿监护室内的孕龄、年龄、出生体重和原发病均相似的患婴作为对照组。结果表明:新生儿屏障功能不完善,多种免疫功能低下,当合并有侵袭性治疗方法等下述因素时,极易发生霉菌感染。感染组静脉高营养与静脉乳化脂肪时间平均长为19.5天,比对照组多8.5天(P=0.009);感染组气管插管和/或气管切开
In recent years, high-risk neonatal systemic fungal infections, especially the increased incidence of bacteremia, systemic infection with low birth weight babies mortality of up to 54%. In order to understand the risk factors of their morbidity, the authors analyzed 20 cases of candidiasis within 4 months of age who had ever lived in neonatal intensive care unit (NICU). In the same period, The age, birth weight and primary disease were similar in infants as a control group. The results show that: neonatal barrier function is not perfect, a variety of immune dysfunction, when combined with invasive treatment methods such as the following factors, prone to mold infection. Infected group, the average duration of intravenous high-nutrition and intravenous emulsified fat was 19.5 days, 8.5 days more than the control group (P = 0.009). In the infection group, tracheal intubation and / or tracheotomy