阵发性睡眠性血红蛋白尿(PNH),是一种获得性红细胞膜异常引起的溶血性疾病。为进一步提高对本病的认识,现将我院近20年收治的40例分析如下。1 临床资料1.1一般资料 40例中男31例,女9例;16岁～77岁,中位年龄39岁;入院前病程7天～20年,中位数2年。1.2临床表现病程中出现血红蛋白尿者33例, Paroxysmal nocturnal hemoglobinuria (PNH) is a haemolytic disease caused by an abnormal erythrocyte membrane. In order to further enhance the understanding of the disease, now 40 cases admitted to our hospital nearly 20 years as follows. 1 Clinical data 1.1 General Information 40 cases of males in 31 cases, 9 females; 16 years old to 77 years, the median age of 39 years; pre-admission course of 7 days to 20 years, the median 2 years. 1.2 clinical manifestations of hemoglobinuria in 33 cases,