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通过酶联免疫吸附法测定10名正常人和48名Ⅱ型糖尿病患者血浆β-血小板球蛋白（βTG）和血小板第四因子（PF4_）的水平，来观察和探讨糖尿病患者体内血小板活性状态，以及与糖尿病激血管病变发病机理的关系。研究发现糖尿病患者血浆βTG水平显著高于正常人（P＜0.01），而血浆PF_4水平在糖尿病患者和正常人中无显著差异（P＞0.05），伴或不伴视网膜病变的糖尿病组间血浆βTG、PF_4水平也无显著差异（P值分别＞0．5、＞0．05）。糖尿病患者血浆β水平与空腹血糖浓度之间呈正相关（r=+0.48,P＜0.05）。提示糖尿病患者体内血小板活性升高，可能是由精代谢紊乱所致；是糖尿病做血管病变发生的原因而并非结果。
The levels of plasma β-thromboglobulin (βTG) and platelet factor 4 (PF4_) in 10 normal subjects and 48 type Ⅱ diabetic patients were measured by enzyme-linked immunosorbent assay (ELISA) to observe and explore the platelet-activating status in diabetic patients and Relationship with Pathogenesis of Diabetic Vascular Diseases. The study found that plasma βTG levels were significantly higher in diabetic patients than in normal people (P <0.01), while there was no significant difference in plasma PF_4 levels between diabetic patients and normal controls (P> 0.05). Plasma βTG in diabetic patients with or without retinopathy , PF 4 levels were also no significant difference (P values were> 0.5,> 0.05). There was a positive correlation between plasma β level and fasting plasma glucose in diabetic patients (r = +0.48, P <0.05). Tip of diabetic patients with elevated platelet activity, may be caused by metabolic disorders; diabetes is the cause of vascular disease and not the result.