Objective:To detect the expression of glial fibrillary acid protein (GFAP) and taurine trans- porter (TauT) in the retinal Müller cells in high glucose culture with taurine and to explore the influence of glucose on the taurine transporting,and the possible protective effects of taurine on Müller cells in early diabetic retinopathy.Methods.The Müller cells from the rat retina were cultured in high glucose,and GFAP and TauT expressions were detected in the cells treated with different doses of taurine by immuocy- tochemical fluorescein staining and Western blotting.Results:High glucose enhanced the expression of GFAP and decreased the expression of TauT in Müller cells.Taurine decreased the up-regulation of GFAP in the cells which was induced by high glucoses 0.1-10mmol/L taurine increased the expression of TauT in Müller cells.Conclusion:Taurine can inhibit the changes in Müller cell resulted from high glucose. Objective: To detect the expression of glial fibrillary acid protein (GFAP) and taurine trans-porter (TauT) in the retinal Müller cells in high glucose culture with taurine and to explore the influence of glucose on the taurine transporting, and the possible protective effects of taurine on Müller cells in early diabetic retinopathy. Methods. The Müller cells from the rat retina were cultured in high glucose, and GFAP and TauT expressions were detected in the cells treated with different doses of taurine by immuocytochemical fluorescein staining and Western blotting .Results: High glucose enhanced the expression of GFAP and decreased the expression of TauT in Müller cells. Taurine decreased the up-regulation of GFAP in the cells which was induced by high glucoses 0.1-10 mmol / L taurine increased the expression of TauT in Müller cells.Conclusion: Taurine can inhibit the changes in Müller cell resulted from high glucose.