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目的探讨姑息手术联合125I粒子植入治疗无法切除的晚期胰腺癌近期临床疗效。方法选择无法手术切除的胰腺癌患者98例,其中支持治疗53例(Ⅰ组);姑息手术(胆肠吻合术和或胃空肠吻合术)24例(Ⅱ组);姑息手术联合术中125I粒子植入治疗21例(Ⅲ组)。结果Ⅲ组患者疗后疼痛部分缓解率及完全缓解率分别为84.21%(16/19)及15.79%(3/19),均显著高于其他两组(P<0.001);Ⅲ组患者的中位生存期为8.6个月,长于Ⅱ组患者的5.7个月及Ⅰ组患者的4.5个月(P<0.05)。结论对不可切除的晚期胰腺癌行125I粒子植入治疗可以延长患者生存期(部分病例还可长期生存),且能缓解疼痛并提高生活质量。
Objective To investigate the short-term clinical effect of palliative surgery combined with 125I seed implantation in the treatment of unresectable advanced pancreatic cancer. Methods A total of 98 patients with unresectable pancreatic cancer were selected, including 53 patients in supportive therapy (group Ⅰ), 24 patients underwent palliative surgery (cholecystojejunostomy or gastrojejunostomy) (group Ⅱ), palliative surgery combined with 125I 21 cases were implanted (group Ⅲ). Results The pain relief rate and complete remission rate of patients in group Ⅲ were 84.21% (16/19) and 15.79% (3/19) respectively, which were significantly higher than those in the other two groups (P <0.001). In group Ⅲ, The median survival was 8.6 months, longer than 5.7 months in patients in group II and 4.5 months in patients in group I (P <0.05). Conclusion The 125I seed implantation for unresectable advanced pancreatic cancer can prolong the survival of patients (some cases can also be long-term survival), and can relieve pain and improve quality of life.