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目的探讨妊娠期高血压疾病患者胎盘组织血管病变的机理,以期为进一步认识妊娠期高血压疾病的病因以及对其防治开辟新途径。方法采用SABC法检测30例正常足月妊娠孕妇及90例妊娠期高血压疾病患者胎盘组织中VEGF蛋白的表达并计数MVD。结果子痫前期、子痫患者胎盘组织中VEGF蛋白表达低于对照组,且与MVD值呈正性相关。结论VEGF参与了胎盘组织血管病变机理过程,其表达异常可能与妊娠期高血压疾病的病因及病理过程有关。
Objective To investigate the mechanism of placental vascular disease in patients with hypertensive disorders during pregnancy in order to further understand the cause of hypertensive disorders in pregnancy and to open up new ways for its prevention and treatment. Methods SABC method was used to detect the expression of VEGF protein in placentas of 30 normal pregnant women and 90 cases of hypertensive disorders of pregnancy. The MVD was counted. Results The expression of VEGF protein in placenta of preeclampsia and eclampsia was lower than that in control group, and positively correlated with MVD. Conclusion VEGF is involved in the pathogenesis of placental vascular disease. The abnormal expression of VEGF may be related to the etiology and pathological process of hypertensive disorder complicating pregnancy.