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有12～33%痛经患者口服强有力的前列腺素(PG)合成抑制剂后症状不能减轻。这与PG是原发性痛经病因的想法是矛盾的。由于19～89%的痛经患者常伴随着呕吐,作者也曾用Naproxen的直肠栓剂做过小规模试验,观察到92%患者的痛经症状得到很好或较好的缓解,因此呕吐可能是治疗失败的原因。为了探讨这个问题作者用双盲双哑交叉试验法,将Naproxen的片剂和栓剂在原发性痛经中的疗效进行比较。方法为选择40名年龄在17～33岁之间的志愿受试患者,均为未产妇,除了患痛经外,无其它病史。骨盆及一般检查正常。将二个疗程的药品给予每个患
In 12 to 33% of dysmenorrhea patients, oral potent prostaglandin (PG) synthesis inhibitors can not relieve their symptoms. This is contradictory to the idea that PG is the etiology of primary dysmenorrhea. Since 19 to 89% of dysmenorrhea patients are often accompanied by vomiting, the authors have also conducted small-scale trials with Naproxen’s rectal suppositories and found that 92% of patients had good or better dysmenorrhea symptoms and vomiting may be a failure of treatment s reason. To explore this issue, the authors compared the efficacy of Naproxen tablets and suppositories in primary dysmenorrhea using a double-blind double dumb crossover test. Method for the selection of 40 volunteers aged 17 to 33 years of age, were mothers, except with dysmenorrhea, no other history. Pelvis and the general examination is normal. Give two courses of medication to each affliction