血清阴性重症肌无力研究进展

来源 :中国神经免疫学和神经病学杂志 | 被引量 : 0次 | 上传用户：b777300

【摘要】

：

乙酰胆碱受体(acetylcholine receptor,AChR)抗体阴性的重症肌无力(myasthenia gravis,MG)称为血清阴性重症肌无力(SNMG).SNMG在发病机制、临床表现和治疗上都与AChR抗体阳性

【作者】

：

曾秋明

【机构】

：

410008,中南大学湘雅医院神经内科;

【出处】

：

中国神经免疫学和神经病学杂志

【发表日期】

：

2012年6期

【关键词】

：

血清阴性重症肌无力肌肉特异性酪氨酸激酶抗体低亲和力乙酰胆碱受体抗体低密度脂蛋白受体相关蛋白抗体

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乙酰胆碱受体(acetylcholine receptor,AChR)抗体阴性的重症肌无力(myasthenia gravis,MG)称为血清阴性重症肌无力(SNMG).SNMG在发病机制、临床表现和治疗上都与AChR抗体阳性MG不同.近年来研究者在SNMG患者血清中发现多种MG相关抗体,如肌肉特异性酪氨酸激酶(muscle-specific receptor tyrosine kinase,MuSK)抗体、低亲和力AChR抗体、低密度脂蛋白受体相关蛋白4(low density lipoprotein receptorrelated protein 4,LRP4)抗体等.本文就SNMG发病机制与临床表现的研究进展做一简要综述.

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