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氨基糖甙类、灭滴灵和青霉素衍生物联合应用作为治疗腹腔内感染的辅助措施已被普遍采用,目前,新一代具有更广抗菌谱的抗生素也已投入应用,但各种临床对照尚未发现有治疗效果上的明显差别。本文通过前瞻性随机研究,观察对需手术治疗的严重腹腔内感染患者单独应用头孢双硫唑甲氧(Cefotetan)和联合应用氨苄青霉素、庆大霉素、灭滴灵(AGM)的效果。 14岁以上需手术治疗的腹腔内感染患者100例,随机分成两组分别接受Cefotetan和AGM治疗。Cefotetan用法为2g静脉注射每12小时一次,庆大霉素80mg每8小时一次,氨苄青霉素1g每6小时一次,灭滴灵500mg每8小时一次。于术前给第一次剂
A combination of aminoglycosides, metronidazole and penicillin derivatives has been widely adopted as an adjunct to the treatment of intraperitoneal infections. A new generation of antibiotics with broader antimicrobial spectrum has also been used, but various clinical controls have not been found There are significant differences in the treatment effect. In this prospective, randomized, prospective, randomized study, the efficacy of Cefotetan combined with ampicillin, gentamicin and metronidazole (AGM) alone in patients with severe intraperitoneal infections requiring surgery was observed. 100 patients with intraperitoneal infection requiring surgery over the age of 14 were randomly divided into two groups receiving cefotetan and AGM respectively. Cefotetan usage 2g intravenous injection once every 12 hours, gentamicin 80mg once every 8 hours, ampicillin 1g every 6 hours, metronidazole 500mg every 8 hours. Give the first dose before surgery