1981年,乙肝疫苗在美国获准生产,几个月后许多欧洲国家也批准生产该疫苗。那时约三百万人接种了乙肝疫苗,充分证明了早期的研究结论。在健康成年人群中,90％以上接种三次疫苗者可产生保护性抗体,即抗-HBs。免疫保护作用达90％,副反应轻微,没有由于接种疫苗而发生乙型、非甲非乙型肝炎和 In 1981, hepatitis B vaccine was allowed to be produced in the United States. A few months later, many European countries also approved the vaccine. At that time, about three million people were vaccinated against hepatitis B, which fully proved the early findings. In healthy adults, more than 90% of those vaccinated with three vaccines produce protective antibodies, anti-HBs. Immunoprotective effect of up to 90%, minor side effects, did not occur as a result of vaccination B, non-A non-B hepatitis and