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目的探讨人涎液和胃液中表皮生长因子（ｈＥＧＦ）水平与消化性溃疡（ＰＵ）的关系．方法应用放免分析（ＲＩＡ）药盒，检测消化性溃疡８４例，慢性胃炎６５例和正常人２０例的涎液和胃液中的ｈＥＧＦ含量．结果消化性溃疡患者的ｈＥＧＦ（μｇ／Ｌ）在涎液（２１０±０９８及２１０±１０７）、胃液（１２５±０９９及１１８±０６３）均显著低于正常对照组（涎液２７４±１３１、胃液１８１±０９０）和慢性胃炎组（涎液２５７±１５４、胃液１５９±１３５）（Ｐ＜００５），活动期（Ａ期）消化性溃疡患者涎液中ｈＥＧＦ含量明显低于愈合期（Ｓ期）的患者（Ｐ＜００５）．结论测定涎液ｈＥＧＦ水平有助于对消化性溃疡患者的诊断和治疗．
Objective To investigate the relationship between the level of epidermal growth factor (hEGF) in human salivary fluid and gastric juice and peptic ulcer (PU). Methods Radioimmunoassay (RIA) kit was used to detect hEGF content in salivary fluid and gastric juice in 84 cases of peptic ulcer, 65 cases of chronic gastritis and 20 cases of normal persons. Results The hEGF (μg / L) in patients with peptic ulcer was higher in salivary fluid (210 ± 098 and 210 ± 107), gastric juice (125 ± 099 and 118 ± 063 ) Were significantly lower than the normal control group (saliva 2 74 ± 1 31, gastric juice 1 81 ± 0 90) and chronic gastritis group (saliva 2 57 ± 1 54, gastric juice 1 59 ± 1 35) (P <005). The activity of hEGF in the salivary fluid of patients with peptic ulcer was significantly lower than that of patients in the active phase (A) (P <005). Conclusion The determination of hEGF level in salivary fluid is helpful for the diagnosis and treatment of patients with peptic ulcer.