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NF-IL6(nuclear factor for interleukin 6 expression)是C/EBP家族成员之一,它对多种基因均能进行调控.我们曾发现NF-IL6的过量表达可以提高NIH3T3细胞的成瘤性,提示NF-IL6与肿瘤形成有关.虽然有报道表明在正常情况下,NF-IL6在人类正常组织中无明显表达,体外培养的肿瘤细胞系HepG2、HepG3、CHU-2等细胞中有组成性表达,但人体内肿瘤组织中NF-IL6的表达情况如何目前尚未见报道.为了观察NF-IL6在人实体瘤中的表达情况,进一步证实NF-IL6与肿瘤的关系,我们收集了3O例肿瘤标本,其中胃癌9例、肝癌5例、乳腺癌1例、肺癌2例,其它肿瘤13例,所有肿瘤均取之于外科手术,患者在手术前未接受化
NF-IL6 (nuclear factor for interleukin 6 expression) is one of the members of the C/EBP family and it regulates many genes. We have found that overexpression of NF-IL6 can increase the tumorigenicity of NIH3T3 cells, suggesting that -IL6 is associated with tumor formation. Although it has been reported that under normal circumstances, NF-IL6 is not significantly expressed in human normal tissues, the tumor cell lines cultured in vitro have constitutive expression in HepG2, HepG3, CHU-2 cells, but The expression of NF-IL6 in human tumor tissues has not been reported at present. In order to observe the expression of NF-IL6 in human solid tumors and further confirm the relationship between NF-IL6 and tumors, we collected 3O cases of tumor specimens. 9 cases of gastric cancer, 5 cases of liver cancer, 1 case of breast cancer, 2 cases of lung cancer, and 13 cases of other tumors. All tumors were taken for surgery and patients were not accepted before surgery.