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目的:探讨人血清凝集肿瘤细胞活性检测在恶性肿瘤临床诊断及预后的意义.方法:采用体外细胞凝集实验,通过半定量计算肿瘤细胞凝集率测定血清的活性.结果:正常人、良性肿瘤患者及恶性实体瘤患者的血清均不同程度地诱导高转移潜能人鼻咽癌细胞(CNE-2L2)凝集,凝集率分别为28.2±8.3%、33.7±9.1%和68.3±10.8%.血清凝集肿瘤细胞活性检测在恶性肿瘤诊断上的阳性率为94.2%,特异性为93.7%,准确性为94.0%.结论:研究结果提示人血清凝集肿瘤细胞活性可能是一潜在的广谱恶性肿瘤标志,在恶性肿瘤的临床诊断、病情控制及预后上具有重要应用价值和广阔的应前前景.
Objective: To explore the significance of detection of human serum agglutination tumor cell activity in clinical diagnosis and prognosis of malignant tumors. Methods: In vitro cell agglutination test was used to determine the activity of serum by semiquantitatively calculating the rate of tumor cell agglutination. Results: Normal and benign tumor patients The serum of patients with malignant solid tumors induced agglutination of nasopharyngeal carcinoma cells (CNE-2L2) with high metastatic potential. The agglutination rate was 28.2±8.3%, 33.7±9.1%, and 68.3±10.8%, respectively. Serum agglutination activity of tumor cells The positive rate of detection in malignant tumors was 94.2%, the specificity was 93.7%, and the accuracy was 94.0%. Conclusion: The results suggest that the activity of human serum agglutinating tumor cells may be a potential marker of a broad-spectrum malignancy in malignant tumors. The clinical diagnosis, disease control and prognosis have important application value and broad prospects.