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目的比较pQCT与DXA定量检测去卵巢大鼠股骨近端骨质疏松的建模效果的能力。方法16只8月龄Wistar雌性大鼠(平均体重350g)随机分为模型组(卵巢切除组)与对照组(卵巢假切除组)。术后3个月,取大鼠左侧股骨。应用肢体计算机断层扫描(pQCT)与双能X线骨密度仪(DXA)对骨质疏松建模效果进行对比研究:(1)确定pQCT与DXA测量精度,即计算重复测量的精度误差;(2)比较应用两种骨密度仪所测得的对照组、模型组的骨密度、骨矿含量、骨几何结构参数及其相关系数。结果(1)pQCT总骨及松质骨体密度的测量精度误差分别为2.27%与2.00%,而DXA骨面密度的测量精度误差为3.36%。(2)模型组pQCT总骨体密度和松质骨体密度分别低于对照组8.2%和15.0%犤(模型组-对照组)/对照组×100%犦,差异有显著性(P<0.01);而模型组DXA骨面密度低于对照组3.0%,差异无显著性(P>0.05)。模型组pQCT总骨骨矿含量低于对照组3.7%,差异无显著性(P>0.05),而松质骨骨矿含量低于对照组11.4%,差异有显著性(P<0.05);模型组DXA骨矿含量低于对照组3.0%,差异无显著性(P>0.05)。(3)DXA骨矿含量与pQCT总骨骨矿含量之间呈正相关(r=0.82,P<0.001);DXA骨投影面积与pQCT骨体积之间亦呈正相关(r=0.52,P<0.05);DXA骨面密度与pQCT总骨体密度之间无相关关系(r=0.14,P>0.05)。DXA?
Objective To compare the ability of pQCT and DXA to quantitatively detect the modeling effect of proximal femur osteoporosis in ovariectomized rats. Methods Twenty-six female Wistar rats of 8 months old (mean body weight 350g) were randomly divided into model group (ovariectomized group) and control group (ovariectomized group). Three months after operation, the left femur of rats was taken. To compare the modeling results of osteoporosis with limb-bone computed tomography (pQCT) and dual-energy X-ray absorptiometry (DXA): (1) To determine the measurement accuracy of pQCT and DXA, that is, to calculate the accuracy error of repeated measurements; ) Comparison of bone mineral density, bone mineral content, bone geometry parameters and their correlation coefficients measured by two kinds of bone densitometry in the control group, model group. Results (1) The error of measurement accuracy of total bone and cancellous bone mass of pQCT were 2.27% and 2.00% respectively, while that of DXA bone surface density was 3.36%. (2) The total body density and cancellous bone density of pQCT in the model group were significantly lower than those in the control group (8.2% vs 15.0% 犤 (model group - control group) / control group × 100% (, respectively) ). The bone density of DXA in the model group was lower than that of the control group by 3.0%, with no significant difference (P> 0.05). The bone mineral content of pQCT in the model group was lower than that of the control group (3.7%) (P> 0.05), but the content of cancellous bone mineral was lower than that of the control group (11.4%) (P <0.05) Group DXA bone mineral content was lower than the control group 3.0%, no significant difference (P> 0.05). (3) There was a positive correlation between bone mineral content of DXA and total bone mineral content of pQCT (r = 0.82, P <0.001). There was also a positive correlation between DXA bone projection area and pQCT bone volume (r = 0.52, There was no correlation between DXA bone density and total body density of pQCT (r = 0.14, P> 0.05). DXA?