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目的:考察注射用头孢地嗪钠、注射用头孢西丁钠分别与5%转化糖注射液配伍的稳定性,为临床合理用药提供科学依据。方法:在室温(25±1)℃下,将这两种药分别与5%转化糖注射液配伍,在6 h内,观察各配伍溶液的pH和外观变化,并采用HPLC法测定各配伍溶液中主药成分的相对含量。结果:头孢地嗪钠、头孢西丁钠与5%转化糖注射液配伍6 h内pH、外观和相对含量均有明显变化。结论:注射用头孢地嗪钠和注射用头孢西丁钠5%转化糖注射液的配伍液不稳定。
Objective: To investigate the stability of cefodizime sodium for injection and cefoxitin sodium for injection and 5% invert sugar injection, respectively, to provide a scientific basis for clinical rational drug use. Methods: The two drugs were respectively matched with 5% invert sugar injection at room temperature (25 ± 1) ℃. The pH and the appearance of each compatibility solution were observed within 6 h. The compatibility of each compatibility solution The main drug ingredients in the relative content. Results: The pH, appearance and relative content of cefodizime sodium, cefoxitin sodium and 5% invert sugar injection within 6 h were obviously changed. Conclusion: The compatibility of cefodizime sodium for injection and cefoxitin sodium 5% invert sugar for injection is not stable.