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目的 研究硒、锌对氟在大鼠体内吸收、排泄和蓄积过程的影响 方法 大鼠饮水中加入NaF（100 mg/L）,灌胃给子Na2SeO3 0.1mg/（kg·d）或（和）ZnSO4 17.5 mg/（kg·d）,试验共90d。测定血氟、粪氟、尿氟和骨氟含量。结果给予Na2SeO3和（或）ZnSO4可升高尿氟浓度,降低血氟浓度和骨氟含量。给予ZnSO4及同时给予Na2SeO3、ZnSO4使粪氟含量升高。结论 给予ZnSO4可阻碍氟在肠道的吸收,给予Na2SeO3或（和）ZnSO4可促进尿氟排泄,阻断氟在骨骼中的蓄积。
Objective To study the effect of selenium and zinc on the absorption, excretion and accumulation of fluoride in rats.Methods Rats were infused with NaF (100 mg / L), Na 2 SeO 3 0.1 mg / (kg · d) ZnSO4 17.5 mg / (kg · d), the test a total of 90d. Determination of blood fluoride, fecal fluoride, urine fluoride and bone fluoride content. The results given Na2SeO3 and (or) ZnSO4 can increase urinary fluoride concentration, lower blood fluoride levels and bone fluoride content. Given ZnSO4 and given Na2SeO3, ZnSO4 so that faecal fluorine content increased. Conclusion The administration of ZnSO4 can hinder the absorption of fluoride in the intestine, and the administration of Na2SeO3 or (and) ZnSO4 can promote urinary fluoride excretion and block the accumulation of fluoride in the bone.