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丝裂霉素C(mitomycin C,MMC)为一抗生素类抗癌药物,多用于粒细胞性白血病及胃癌、结肠癌等实体瘤的治疗。由于其细胞毒作用选择性不强,常出现骨髓抑制及胃肠道反应等现象。克服这一严重缺点的方法是将它与针对肿瘤组织的单克隆抗体相连接以对肿瘤组织实行导向治疗。我们选
Mitomycin C (MMC) is an antibiotic anticancer drug used for the treatment of solid tumors such as myeloid leukemia, gastric cancer and colon cancer. Because of its cytotoxicity is not selective, often appear bone marrow suppression and gastrointestinal reactions and so on. One way to overcome this serious disadvantage is to link it to a monoclonal antibody to tumor tissue for targeted therapy of the tumor tissue. We choose