论文部分内容阅读
抑郁障碍是癫痫患者最常见的精神系统并发症，癫痫共患抑郁的高患病率提示二者之间可能存在一些潜在的共同发病机制。神经元突触可塑性改变与突触结构异常改变、神经网络异常及多种突触蛋白表达密切相关。研究显示，神经元突触可塑性改变及再生异常在癫痫与抑郁障碍共患病的发生机制中发挥重要作用，本文现围绕二者之间的联系综述如下。“,”Depression is the most common mental complication in patients with epilepsy. The high prevalence of epilepsy combined with depression suggests that there may exist potential co-morbid mechanisms between them. Synaptic plasticity and regeneration of neurons abnormality play important roles in the occurrence of epilepsy combined with depression. Changes in neuronal synaptic plasticity are closely related to abnormal changes in neural structure, abnormal neural networks and expressions of various synaptic proteins. Changes in synaptic plasticity and abnormal regeneration play important roles in the pathogenesis of epilepsy and depression. This paper summarizes the relation between epilepsy combined with depression and neuronal synaptic plasticity.