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目的和方法：为探讨内皮素在肾缺血／再灌注损伤中的发病学意义，本实验在大鼠肾缺血／再灌注损伤模型上，观察了内皮素抗体对肾缺血／再灌注损伤的作用。结果：肾缺血／再灌注损伤大鼠，血清尿素氮（ＳＵＮ）、肌酐（ＳＣｒ）含量及血浆内皮素（ＰＥＴ）水平显著升高；脂质过氧化物丙二醛（ＭＤＡ）产生增多；肾小管上皮细胞明显损伤。应用内皮素单克隆抗体能显著降低ＰＥＴ水平和ＭＤＡ含量，减轻肾小管上皮细胞损伤，改善肾功能。结论：内皮素是参与肾缺血／再灌注损伤发病的重要因素之一，阻断ＥＴ的生物学作用是防治肾缺血／再灌注损伤的有效途径。
Purpose and Methods: To investigate the pathogenesis of endothelin in renal ischemia-reperfusion injury, we observed the effect of endothelin-antibody on renal ischemia / reperfusion injury in rat model of renal ischemia / reperfusion injury Role. Results: Serum urea nitrogen (SUN), creatinine (SCr) and plasma endothelin (ET) levels were significantly increased in rats with renal ischemia / reperfusion injury and the production of lipid peroxides malondialdehyde (MDA) Tubular epithelial cells were significantly damaged. Application of endothelin monoclonal antibody can significantly reduce the PET level and MDA content, reduce renal tubular epithelial cell damage, improve renal function. Conclusion: Endothelin is one of the important factors involved in the pathogenesis of renal ischemia / reperfusion injury. Blocking the biological function of ET is an effective way to prevent renal ischemia / reperfusion injury.