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目的探讨川崎病(KD)发生冠状动脉病变(CAL)的危险因素。方法回顾性分析2000年1月至2004年12月期间942例住院KD患儿的临床资料,对发生CAL(170例)和未发生CAL(772例)的病例进行组间对照研究,对13种影响CAL发生的因素进行Logistic回归分析。结果Logistic回归分析结果表明,热程大于10d(X1)的OR值为1.203(95%CI=1.104～1.312,P<0.001)、血红蛋白(Hb)小于100g/L(X2)的OR值为0.658(95%CI=0.472～0.995,P<0.05)。建立KD发生CAL的危险因素主效应模型是Logit(P)=β0(-2.995)+0.185X1+(-0.378)X2(χ2=16.920,P=0.031)。结论热程大于10d、Hb<100g/L是KD发生CAL的高危因素。
Objective To explore the risk factors of coronary artery disease (KD) in Kawasaki disease (KD). Methods The clinical data of 942 hospitalized children with KD from January 2000 to December 2004 were retrospectively analyzed. An intergroup controlled study of CAL (170 cases) and non-CAL (772 cases) Factors affecting the occurrence of CAL were analyzed by Logistic regression. Results The logistic regression analysis showed that the odds ratio was 1.203 (95% CI = 1.104-1.312, P <0.001), and the OR of Hb> 100g / L (X2) was 0.658 95% CI = 0.472 ~ 0.995, P <0.05). The main effect of establishing risk factors for CAL in KD was logit (P) = β0 (-2.995) + 0.185X1 + (- 0.378) X2 (χ2 = 16.920, P = 0.031). Conclusions The heat stroke of more than 10 days, Hb <100g / L is the risk factor of KD in CAL.