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目的 探讨 P16蛋白在非小细胞肺癌 ( NSCLC)及癌旁组织中的表达及临床意义。方法 采用 SP免疫组化方法测定 P16蛋白在 64例 NSCL C及癌旁 1～ 2 cm组织中的表达。结果 P16蛋白的阳性表达主要位于细胞胞浆 ,部分同时出现于胞核。P16蛋白在 NSCL C中的表达率为4 0 .6% ,在癌旁组织中的表达率为 74 .4 % ,与 NSCL C的分化程度及患者术后生存期有关 ( P<0 .0 5) ,而与组织学类型及有无局部淋巴结转移无明显关系 ( P>0 .0 5)。结论 P16蛋白表达缺失可作为临床判断 NSCL C的分化程度及预测患者预后的参考指标
Objective To investigate the expression and clinical significance of P16 protein in non-small cell lung cancer (NSCLC) and adjacent tissues. Methods SP immunohistochemical method was used to determine the expression of P16 protein in 64 cases of NSCL C and 1-2 cm adjacent tissues. Results The positive expression of P16 protein was mainly located in the cytoplasm and partly appeared in the nucleus. The expression rate of P16 protein in NSCL C was 40.6%, and it was 74.4% in paracancerous tissue, which was related to the differentiation of NSCL C and the survival time of patients (P<0.05). ), but not with the histological type and the presence or absence of regional lymph node metastasis (P> 0.05). Conclusion The loss of P16 protein expression can be used as a reference index to determine the differentiation of NSCL C and predict the prognosis of patients.