环胞素(Cyclosporine A,CSA)是一强效免疫抑制剂,用于预防异体器官移植后的排斥反应和治疗自体免疫性疾病。但在临床和实验研究中,发现CSA可引起高血压、高血糖、骨质疏松、血栓形成及神经系统副作用,特别是肾脏毒性反应。最近报道,心脏移植病人应用CSA后出现了心力衰竭。因此,本实验观察CSA对离体豚鼠左心房收缩性的影响,以探讨CSA对心肌的毒性作用。 Cyclosporine A (CSA) is a potent immunosuppressive agent used to prevent rejection after allogeneic organ transplantation and to treat autoimmune diseases. However, in clinical and experimental studies, CSA was found to cause hypertension, hyperglycemia, osteoporosis, thrombosis and neurological side effects, especially renal toxicity. It has recently been reported that heart failure occurs after heart transplantation in CSA patients. Therefore, this study observed the effects of CSA on left atrial contractility in isolated guinea pigs to investigate the toxic effects of CSA on myocardium.