消化道的粘膜属于机体的第一道防线.抗原物质如细菌、病毒及大分子异物需通过这层屏障结构,刺激位于消化道壁的淋巴组织以引起免疫反应.Owen等发现回肠Peyer淋巴集结表面覆盖一种特殊的上皮细胞,因其游离面为不规则的微皱褶而非微绒毛,命名为微皱褶细胞(microfold cell),简称为M细胞.随后对M细胞的形态和功能进行了广泛研究.从而 Gastrointestinal mucosa is the body’s first line of defense.Antigen substances such as bacteria, viruses and macromolecular foreign body through this barrier structure, to stimulate the digestive tract wall lymphoid tissue to cause immune response.Owen et al found ileum Peyer lymph node assembly surface Cover a special epithelial cells, because of its free surface irregular micro-folds rather than microvilli, named microfold cell (microfold cell), referred to as M cells.Next M cell morphology and function were Extensive research