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目的分析东莞市塘厦镇免费宫颈癌筛查结果,探讨宫颈癌普查的临床价值。方法对塘厦镇2012年10月至2013年9月共5 368例35~59岁妇女采用妇科常规、液基细胞学检查(TCT)和HPV-DNA检测,对TCT和(或)高危型HPV阳性患者行阴道镜检查及必要的宫颈组织活检,比较各检查方法的阳性率。结果人群筛查中HPV阳性率(7.94%)高于TCT阳性率(1.27%);但组织活检阳性率TCT(67.65%)高于HPV(35.21%),差异均有统计学意义(P<0.05);TCT及HPV均阳性患者组织活检阳性率83.72%。结论 TCT联合HPV-DNA检测能够明显提高CIN的敏感性及准确性,对CIN早期发现及治疗具有重要的临床意义。
Objective To analyze the results of free cervical cancer screening in Tangxia Town, Dongguan City, and to explore the clinical value of cervical cancer screening. Methods A total of 5 368 women aged 35-59 years old from Tangshan from October 2012 to September 2013 were examined with TCT and HPV-DNA by gynecology, liquid-based cytology (TCT) and HPV-DNA test. Positive patients underwent colposcopy and cervical biopsy necessary to compare the positive rate of each test method. Results The HPV positive rate (7.94%) in crowd screening was higher than that of TCT (1.27%), but the positive rate of tissue biopsy was higher than that of HPV (67.65%), the difference was statistically significant (P <0.05 ). The positive rate of tissue biopsy in patients with positive TCT and HPV was 83.72%. Conclusion TCT combined with HPV-DNA test can significantly improve the sensitivity and accuracy of CIN, which has important clinical significance for the early detection and treatment of CIN.