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糖尿病肾病已经成为糖尿病患者进入终末期肾脏病的主要病因，危害着人类的健康。肾素－血管紧张素系统（ RAS）阻滞剂能够降低糖尿病肾病的尿蛋白，广泛应用于临床。常规剂量的RAS阻滞剂不能有效阻滞组织中的RAS，对于糖尿病肾病肾衰竭的延缓作用较弱。大剂量，甚至超大剂量的RAS阻滞剂能更加安全有效地降低糖尿病肾病的尿蛋白，延缓肾衰竭。结缔组织生长因子以及巨噬细胞因子可作为新的诊断糖尿病肾病肾功能进展的指标。“,”Diabetic nephropathy has become the main cause of end-stage renal disease in diabetic patients,and seriously endanger the human health.Renin-angiotensin system( RAS) blockers can reduce the urine protein level in patients with diabetic nephropathy ,that it has been widely used in clinic .Regular doses of the renin-angiotensin system blockers cannot effectively block rennin-angiotensin system in the organiza-tion,and contributes quite little to delaying the renal failure in patients with diabetic nephropathy .However, high doses,even very high doses of the RAS blockers can safely and effectively reduce the urine protein level in patients with diabetic nephropathy,and delay the renal failure.Connective tissue growth factor and macro-phage factor can be used as new diagnostic indicators of renal function development in patients with diabetic nephropathy.