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目的 观察复肝灵煎剂对慢性活动性乙型肝炎的治疗效果。方法 90例慢性活动性乙型肝炎病人被分为试验组和对照组,试验组6 0例服用复肝灵煎剂治疗,每次口服10ml,bid ;对照组30例im干扰素,5 0 0万u/次,隔日一次。2组都同时给维生素C和护肝片以辅助治疗。治疗前后所有病人都做肝功能(蛋白及AST ,ALT)和血清乙肝标志物(HBsAg ,HBeAg ,抗HBc IgM ,抗HBs,抗HBe)检测。疗效的判断分为治愈、显效、有效和无效。结果 试验组治愈2 6例(43.33% ) ,显效2 6例(43.33% ) ,有效6例(10 % ) ,无效2例(3.33% ) ,总有效率为96 .6 7% ,明显高于对照组的83.33% (P <0 .0 5 ) ;HbsAg和HbeAg的阴转率分别为4 3.3%和4 6 .4 5 % ,均高于对照组的2 3.33%和4 3.33% (P <0 .0 5 )。结论 复肝灵对慢性活动性乙型肝炎疗效显著,治疗效果优于干扰素。
Objective To observe the therapeutic effect of Fugan Ling decoction on chronic active hepatitis B. Methods Ninety patients with chronic active hepatitis B were divided into trial group and control group. 60 cases in trial group were treated with Fugan Ling decoction, each time oral 10ml, bid; control group, 30 cases of interferon, Million u / time, every other day. 2 groups also give vitamin C and liver tablets for adjuvant therapy. Before and after treatment, all patients were tested for liver function (protein and AST, ALT) and serum hepatitis B markers (HBsAg, HBeAg, anti-HBc IgM, anti-HBs, anti-HBe). The curative effect is divided into cured, markedly effective, effective and ineffective. Results The experimental group cured 26 cases (43.33%), markedly effective in 26 cases (43.33%), effective in 6 cases (10%) and ineffective in 2 cases (3.33%), with a total effective rate of 96.67% The negative conversion rate of HbsAg and HbeAg were 43.3% and 46.5%, respectively, which were both higher than 23.33% and 4.33% of the control group (P <0. 05) 0 .0 5). Conclusion Fuganling has significant curative effect on chronic active hepatitis B, and its curative effect is better than that of interferon.