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目的：观察巴曲抗栓酶治疗糖尿病性周围神经病变的疗效并与尿激酶作比较。方法：糖尿病性周围神经病变病人６５例，治疗组男性２３例，女性１２例，年龄５２±ｓ１３ａ，用巴曲抗栓酶首剂量１０ＢＵ加入０．９％氯化钠注射液５００ｍＬ静脉滴注（静滴），４０滴／ｍｉｎ，隔日剂量５ＢＵ，２ｗｋ为一个疗程共２个疗程；对照组男性１８例，女性１２例，年龄４５±１４ａ，用尿激酶１．５～２万Ｕ加入０．９％氯化钠注射液５００ｍＬ静滴，６０滴／ｍｉｎ，ｑｄ，２ｗｋ为一个疗程共２个疗程。结果：治疗组与对照组有效率分别为９８％和７３％（Ｐ＜０．０５），治疗组生化指标有显著性改善（Ｐ＜０．０５）。结论：巴曲抗栓酶治疗糖尿病性周围神经病变疗效确切，安全可靠。
Objective: To observe the efficacy of batroxobin in the treatment of diabetic peripheral neuropathy and to compare with urokinase. Methods: 65 cases of diabetic peripheral neuropathy patients, treatment group, 23 males and 12 females, age 52 ± s13a, with batroxobin first dose of 10BU added 0.9% sodium chloride injection 500mL intravenous infusion Intravenous infusion), 40 drops / min, every other day dose 5BU, 2wk for a course of a total of 2 courses; control group of 18 males and 12 females, aged 45 ± 14a, urokinase 1.5 ~ 20,000 U added 0. 9% sodium chloride injection 500mL intravenous infusion, 60 drops / min, qd, 2wk for a course of a total of 2 courses. Results: The effective rates of the treatment group and the control group were 98% and 73% respectively (P <0.05), and the biochemical indexes of the treatment group were significantly improved (P <0.05). Conclusion: Batroxobin is effective and safe in the treatment of diabetic peripheral neuropathy.