本文报道用链脲佐菌索给Wistar大鼠腹腔一次注射,建立了实验性糖尿病模型。实验动物血糖反应呈三时相变化:初期高血糖相(2小时),低血糖相(6～12小时)和糖尿病血糖相(24小时～12周)。为进一步研究糖尿病发病机理、并发症、治疗实验和筛选新的抗糖尿病药物等提供了一个较好模型。所建立的模型具有用药量小,方法简便,血糖反应敏感等优点。 This article reports the use of streptozotocin to Wistar rats intraperitoneal injection, the establishment of an experimental diabetic model. Blood glucose responses in experimental animals developed three phases: initial hyperglycemic phase (2 hours), hypoglycemic phase (6-12 hours), and diabetic blood glucose phase (24 hours - 12 weeks). It provides a better model for further research on the pathogenesis of diabetes, complications, therapeutic experiments and screening of new antidiabetic drugs. The established model has the advantages of small dosage, simple method and sensitive response to blood glucose.