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冠状动脉搭桥术后约有30～60%患者发生高血压,在功能和代谢尚未完全恢复的阶段,它造成严重的血液动力学应激状。硝酸甘油(NTG)可增进缺血心肌灌注,理论上治疗术后高血压比硝普钠(NP)更为优越。本文65例冠状动脉搭桥术后有36例(55%)术后四小时出现高血压(平均动脉压(MAP)>95mmHg),随机静注NTG(1.0 mg/ml)或NP(0.1mg/ml)使平均动脉压下降至85mmHg。治疗前后记录测定的动脉压。然后停药,待血压升至高血压水平后,再给另一种药物治疗以作比较。结果显示在控制高血压方面,两者均有效。NTG降低左室前、后负荷及心搏击作功指数优于NP,降低心肌氧耗量比
About 30 to 60% of patients after coronary artery bypass grafting develop hypertension, which causes severe haemodynamic stress during the phase of functional and metabolic failure. Nitroglycerin (NTG) increases ischemic myocardial perfusion and theoretically treats postoperative hypertension more than sodium nitroprusside (NP). Thirty-six (55%) of 65 patients undergoing coronary artery bypass grafting developed hypertension (mean arterial pressure (MAP)> 95 mmHg) four hours after surgery and were randomized to receive NTG (1.0 mg / ml) or NP ) To reduce the mean arterial pressure to 85 mmHg. The measured arterial pressure was recorded before and after treatment. Then stop the drug until the blood pressure rose to high blood pressure level, and then give another drug treatment for comparison. The results show that both are effective in controlling hypertension. NTG reduced left ventricular preload, post-stroke and cardiac stroke work index is better than NP, reduce myocardial oxygen consumption than