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恶性组织细胞病(MH)是一种罕见的急剧进展的致命的病症,伴有发热,肝脾、淋巴结肿大及全血细胞减少。本病的特征是异常的巨噬细胞(组织细胞)增生,并在淋巴结、肝脾、骨髓及其他器官中有吞噬红细胞和白细胞的特点。通常在6—12个月内死亡。本文报导一例患MH的妇女,该患有广泛的肉芽肿,死于组织细胞白血病。电子显微镜和细胞化学的资料,证明病人的恶性细胞起源于单核细胞。
Malignant histiocytosis (MH) is a rare and fatal progression of rapid progression with fever, liver and spleen, enlarged lymph nodes and pancytopenia. The disease is characterized by abnormal macrophages (tissue cells) proliferation, and in lymph nodes, liver and spleen, bone marrow and other organs phagocytosis of red blood cells and white blood cells. It usually dies within 6-12 months. This article reports a case of MH-suffering women who have extensive granulomas and died of histiocytic leukemia. Electron microscopy and cytochemical data to prove that the patient’s malignant cells originated in monocytes.