Aβ(1 42)是阿尔茨海默病(Alzheimer’s disease,AD)脑内老年斑的主要成分,其诱导氧化应激反应是Aβ致脑内神经元损伤和死亡的机制之一。芍药苷是中药芍药的主要有效单体成分,具有抗炎、抗氧化、抑制细胞内钙超载、保护神经元等功能。作者此前的研究也表明,芍药苷能改善Aβ(1-42)海马内注射诱导AD大鼠模型的学习和记忆功能,抑制神经 Aβ (1 42) is a major component of senile plaques in the brain of Alzheimer's disease (AD), and its induction of oxidative stress is one of the mechanisms of Aβ-induced neuronal damage and death in the brain. Paeoniflorin is the main effective monomer component of Chinese medicine peony, with anti-inflammatory, anti-oxidation, inhibition of intracellular calcium overload, neurons and other functions. The authors previous study also showed that paeoniflorin can improve the learning and memory function of AD rat model induced by Aβ (1-42) injection, inhibit nerve