细菌产生抗生素耐药的方式有多种,其中包括对药物的水解或修饰、作用靶位的改变,减少或阻止药物进入菌体细胞等。阻止药物在菌体内积聚是细菌产生抗生素多重耐药的重要手段之一,由细菌的主动外排系统介导。主动外排系统是指细菌细胞内膜存在能量依赖性蛋白质外排泵,通过主动外? Bacteria produce antibiotic resistance in a variety of ways, including the hydrolysis or modification of drugs, the role of target changes, reduce or prevent the drug into cells and so on. Preventing the drug from accumulating in the bacteria is one of the most important ways for the bacteria to produce multiple antibiotics. It is mediated by the bacterial efflux system. Active efflux system refers to the presence of bacterial cell membrane energy-dependent protein efflux pump, through active outside?