尖头并指畸形(Acrocephalosynacty-ism)具有颅缝线封闭早和手足对称并指的特征,临床罕见,迄今文献报道约100余例。本病一般临床特征是智力迟钝,头颅前后径短、高径大、额部突、枕部平、面中部发育差,眼距宽、眼眶浅、眼球突出、视力差、“反先天愚 Acrocephalosynacty-ism has the features of early closed cranial suture and symmetrical hand-foot symmetry, which is rare in clinic. So far, about 100 cases have been reported in the literature. The general clinical features of the disease is mental retardation, head short anteroposterior diameter, large diameter, forehead sudden, occipital flat, poor middle facial development, wide eye, orbital shallow, prominent eye, poor eyesight, "counter-all-natural