Objective:To explore the clinical effect of preventive nursing intervention on deep venous thrombosis rate, nursing satisfaction and average hospitalization time after treatment of lung cancer. Methods:Chinese databases (Wanfang, Weipu and China Knowledge Network) and English databases (Pubmed, Cochrane and Scopus) were searched and read references for relevant research. Statistical analysis was performed using Review Manager 5.3. The odds ratio (OR) and the mean difference (MD) were used as the combined effect values of the comparison groups. Sensitivity analysis was performed by changing the effect model or excluding the literature with a large weight ratio, and the symmetry of the funnel plot was observed for publication bias test. Results:A total of 14 Chinese studies included. Compared with routine nursing intervention, preventive nursing intervention could significantly reduce the rate of deep vein thrombosis after lung cancer treatment [OR=0.16 (0.10, 0.23)], improve nursing satisfaction [OR=6.42 (3.32, 12.41)] and shorten the average hospital stay [MD=-7.41 (-8.16, - 6.65)], without heterogeneous existing. And regardless of whether the lung cancer patient was undergoing resection or chemotherapy, the effect of preventive nursing intervention to reduce the rate of deep vein thrombosis was very significant. Conclusion:Preventive nursing intervention is beneficial to patients with lung cancer, which can significantly reduce the formation rate of deep vein thrombosis, which is worthy of clinical promotion.