多肽小分子能够阻断ERK1/2的核定位可作为抗癌靶向。近日,来自以色列的科学家开发了一种多肽小分子能够阻断ERK1/2核定位进而抑制肿瘤细胞生长,同时对未发生肿瘤转化的细胞无影响,这项研究结果表明,阻断ERK1/2核定位或可成为靶向治疗肿瘤的有效靶点。相关研究发表在在国际学术期刊nature communication上。研究人员指出,ERK1/2正常发挥功能的一大特征是其能够发生核转位,并且ERK1/2能够进行核定位对于其发挥促进细胞增殖功能非常重要。而定位在细胞质内处于 Peptide small molecules can block ERK1 / 2 nuclear localization can be used as anti-cancer target. Recently, scientists from Israel developed a small peptide peptide can block ERK1 / 2 nuclear localization and thus inhibit the growth of tumor cells, while not transforming tumor cells had no effect, the study results show that blocking the ERK1 / 2 nucleus Targeting may be an effective target for targeted therapy of tumors. Relevant research published in the international academic journal nature communication. The researchers point out that one of the hallmarks of the normal function of ERK1 / 2 is its ability to undergo nuclear translocation, and the ability of ERK1 / 2 to perform nuclear localization is important for its role in promoting cell proliferation. While located in the cytoplasm