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目的 探讨鼻咽癌咽旁间隙受侵对患者预后的影响。方法 1987年 1月～ 1994年 12月间对 197例初程治疗的鼻咽癌患者进行CT扫描检查 ,利用SPSS 8.0软件进行单因素和多因素分析影响预后的因素。结果 咽旁间隙受侵对实际生存、无瘤生存及局部控制有影响 (P =0 .0 115 ,P =0 .0 0 35 ,P =0 .0 36 7)。咽旁间隙阴性患者的 5年实际生存率、无瘤生存率和局部控制率分别为87.9%、88.0 %和 96 .9% ,茎突前间隙受侵分别为 75 .0 %、71.2 %和 93.7% ,茎突后间隙受侵分别为6 0 .5 %、5 7.7%和 86 .8%。结论 咽旁间隙受侵影响生存及局部控制 ,当茎突后间隙明显受侵时 ,远处转移的机会增加。
Objective To investigate the influence of parapharyngeal space invasion on the prognosis of patients with nasopharyngeal carcinoma. Methods From January 1987 to December 1994, 197 patients with nasopharyngeal carcinoma undergoing initial treatment were examined with CT scan. SPSS 8.0 software was used to analyze the prognostic factors of unilateral and multiple factor analysis. Results The invasion of parapharyngeal space had an impact on actual survival, disease-free survival and local control (P = .0115, P = .035, P = .0367). The 5-year actual survival rate, tumor-free survival rate and local control rate of patients with negative parapharyngeal space were 87.9%, 88.0% and 96.9% respectively, and the anterior space of styloid process was 75.0%, 71.2% and 93.7 %, And the posterior styloid gap involvement was 60.5%, 5 7.7% and 86.8% respectively. Conclusion The invasion of parapharyngeal space affects the survival and local control. When the posterior apical space is apparently infiltrated, the chance of distant metastasis increases.