目的和方法：对糖尿病Ⅰ组（ＨｂＡ１ｃ为７０６％±０６０％）Ⅱ组（ＨｂＡ１ｃ为１１９７％±１６５％）各７例及对照组（ＨｂＡ１ｃ为４８５％±０２０％）６例的高密度脂蛋白（ｈｉｇｈｄｅｎｓｉｔｙｌｉｐｏｐｒｏｔｅｉｎ，ＨＤＬ）糖化进行检测，同时将ＨＤＬ抗血清提纯为抗ＨＤＬＩｇＧ并用辣根过氧化物酶（ｈｏｒｓｅｒｄｉｓｈｐｅｒｉｏｘｉｄａｓｅ，ＨＲＰ）标记。用酶联免疫受体法测定ＨＤＬ与培养的人胚肺成纤维细胞（ｈｕｍａｎｌｕｎｇｆｉｂｒｏｂｌａｓｔ，ＨＬＦ）受体特异结合。结果：Ⅰ、Ⅱ组及对照组糖化值分别为３９２６±８１０、７２９４±６４０和２０４０±１１０Ｇｌｙｃｏｇｒｏｕｐ／ＨＤＬ，Ⅰ、Ⅱ组ＨＤＬ的细胞受体特异结合低于对照组（Ｐ＜００１），Ⅱ组低于Ⅰ组（Ｐ＜００１）。结论：糖尿病患者ＨＤＬ糖化高于正常人，但其与细胞受体的特异结合却下降 PURPOSE AND METHODS: Seven patients with diabetes mellitus (HbA1c: 706% ± 060%), HbA1c (1197% ± 165%) and control group (HbA1c: 485% ± 0  20%) 6 cases of high-density lipoprotein (HDL) saccharification were detected, while HDL antiserum was purified to anti-HDLIgG and horseradish peroxidase (horserdishperioxidase, HRP) labeling. The specific binding of HDL to cultured human lung fibroblasts (HLF) receptors was determined by enzyme-linked immunosorbent assay. Results: The glycosylation values ​​of group Ⅰ, group Ⅱ and control group were 3926 ± 810, 7294 ± 640 and 2040 ± 110Glycogroup / HDL, respectively. Lower than that of the control group (P <001), while that of the Ⅱ group was lower than that of the I group (P <001). Conclusion: The HDL glycosylation in diabetic patients is higher than that in normal people, but the specific binding to cellular receptors is decreased