论文部分内容阅读
目的 探讨尿激酶对急性脑梗死的溶栓效果及安全性。方法 选择 2 0 0 0 - 12～ 2 0 0 4 - 12潮洲市人民医院 5 7例急性脑梗死患者 ,随机分为治疗组 (32例 )和对照组 (2 5例 )。治疗组起病 3h内给尿激酶 5 0万单位+生理盐水 10 0mL静滴 ,2 0min滴完 ;3～ 6h内用尿激酶 10 0万单位 +生理盐水 15 0mL静滴 ,30min滴完。对照组用低分子肝素 0 4mL皮下注射 ,第 1天 2次 ,以后每天 1次 ,共用 7d。结果 治疗组疗效明显优于对照组 ,治疗组痊愈率为 6 0 5 % ,与对照组基本痊愈率 2 0 %相比较差异有显著性意义 (P <0 0 1) ,治疗组出现 1例黏膜出血 ,不影响疗效。结论 尿激酶静脉溶栓治疗急性脑梗死效果好 ,起病 6h内给尿激酶 5 0～ 10 0万单位溶栓治疗安全有效 ,无明显副作用。
Objective To investigate the thrombolytic efficacy and safety of urokinase in acute cerebral infarction. Methods Fifty-seven patients with acute cerebral infarction in Chaozhou People’s Hospital from 2000-2002 to 2004-04 were randomly divided into treatment group (32 cases) and control group (25 cases). The treatment group within 3h to give urokinase 50,000 units + saline 10 0mL intravenous infusion, 20min drip finished; 3 ~ 6h with 10 million units of urokinase + 150mL normal saline intravenous drip, 30min drip finished. Control group with low molecular weight heparin 0 4mL subcutaneous injection, 1 day 2 times, once daily after a day, sharing 7d. Results The curative effect of the treatment group was obviously better than that of the control group. The cure rate of the treatment group was 65%, which was significantly different from that of the control group (20%) (P <0.01) Bleeding, does not affect the efficacy. Conclusion Intravenous thrombolytic therapy of urokinase has a good effect in treating acute cerebral infarction. It is safe and effective to treat 50-100,000 units of urokinase within 6 hours after onset of thrombolytic therapy without obvious side effects.