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目的:观察特苏尼(托拉塞米)短期治疗慢性重度心衰的疗效。方法:选取60例慢性重症心衰患者,随机分为两组,一组予特苏尼10 mg,另一组为对照组,予呋塞米,治疗3 d,记录两组患者治疗前后24 h尿量、体重、血钾、BNP、射血分数(EF)及左室舒张末经(LVEDD)。结果:治疗前两组各参数无统计学差异;治疗3 d后,特苏尼组EF值增加、左室舒张末经缩小的幅度较对照组大,但两组间无统计学差异(P>0.05),其他各变量特苏尼组较对照组改善明显(P<0.05),尤其是BNP下降明显(P<0.01)。特苏尼组血钾轻度下降,但未出现低钾血症,而对照组有6例低钾血症。结论:短期应用特苏尼可降低BNP,改善心功能,低血钾不良反应轻。
OBJECTIVE: To observe the short-term efficacy of tosunee (torsemide) in the treatment of chronic severe heart failure. Methods: Sixty patients with chronic severe heart failure were randomly divided into two groups. One group was treated with tebufenzide 10 mg and the other was control group. Furosemide was given for 3 days. The patients in both groups were recorded before and after treatment for 24 h Urine output, body weight, serum potassium, BNP, ejection fraction (EF) and left ventricular diastolic pressure (LVEDD). Results: Before treatment, there was no significant difference between the two groups. After 3 days of treatment, the EF value increased and the amplitude of left ventricular end-diastole decreased significantly in the tosufi group, but there was no significant difference between the two groups (P> 0.05). The other variables, such as the tosufini group, were significantly improved compared with the control group (P <0.05), especially BNP decreased significantly (P <0.01). Tertensini group serum potassium decreased slightly, but no hypokalemia, while the control group had 6 cases of hypokalemia. CONCLUSIONS: Short-term use of temsirolimus can reduce BNP, improve cardiac function, and hypokalemia adverse reactions.