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目的从文献计量学的角度统计分析氟喹诺酮类药物在抗结核研究领域的研究概况,为抗感染工作领域研究者提供参考。方法检索PubMed、Web of Science、Embase、中国知网等数据库,运用文献计量学分析方法,对纳入文献的年代、语言、期刊、作者及研究机构、文献类型、研究内容、被引频次等进行统计分析。结果文献共9 526篇,符合要求是3 109篇。文献量总体呈逐年上升趋势,文献中研究较多的药物是左氧氟沙星、环丙沙星、莫西沙星、氧氟沙星等。单篇文章被引频次最高的为181次,研究内容分析为氟喹诺酮类药物体外抗分枝杆菌活性、临床耐药情况、临床试验等。结论氟喹诺酮类药物作为二线抗结核治疗药物在对耐药、耐多药结核病的治疗中表现出良好的治疗效果,联合用药可能降低其耐药发生率,但是关于氟喹诺酮类药物与其他抗结核药物间的相互作用研究相对缺乏,今后可着重开展此方面研究。
Objective To statistically analyze the research status of fluoroquinolones in the field of anti-tuberculosis research from the perspective of biodometrics and provide reference for researchers in anti-infective field. Methods The databases of PubMed, Web of Science, Embase and CNKI were searched and the bibliographic data were collected by using bibliometrics, including the age, language, periodicals, authors and research institutes, types of literature, research contents, analysis. The results of a total of 9 526 articles, meet the requirements is 3 109. The literature volume generally showed an upward trend year by year. More drugs studied in the literature are levofloxacin, ciprofloxacin, moxifloxacin and ofloxacin. The highest citation frequency of a single article was 181 times. The content of the study was the anti-mycobacterial activity, clinical drug resistance and clinical trial of fluoroquinolones in vitro. Conclusion Fluoroquinolones as second-line anti-TB drugs have shown good therapeutic effects in the treatment of multidrug-resistant and multi-drug resistant tuberculosis. Combined treatment may reduce the incidence of drug-resistant fluoroquinolones, but fluoroquinolones and other anti-tuberculosis Drug interactions between the relative lack of research in the future can focus on this area.