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目的：探讨周围型肺癌间质与转移、预后以及ＣＴ表现的关系。材料和方法：利用Ｇｒｏｃｏｔ六胺银染色法测定８７例肺癌的间质主质比，并与ＣＴ表现以及转移、预后情况进行对照分析。结果：鳞癌间质多于腺癌，间质成分的比例与肿瘤大小无直接联系。虽然有分叶征的病例在我们观察的时候瘤内肿瘤主质及间质分布显得很不均匀，但有无分叶征的病人各评分之间并无显著性差异（Ｐ＞０．０５）。不同的瘤肺交界面之间除毛刺征者少间质比例较高外其它无明显差别。胸膜凹陷征与瘤体间质的胶原成分也无显著关联。虽然增强程度不同，其间质比例亦略不同，既增强明显的间质成分略多，增强差一点的间质成分略少。但统计学处理表明，两组差别不显著（Ｐ＞０．０５）。与肺癌微血管密度相关性的比较显示也无显著相关（嗜银染色积分１－２分的ＭＶＤ平均５０．１３±１４．５６，积分３－５分的ＭＶＤ平均５３．６７±１２．７１），这说明肺癌增强程度与间质无明显关联。统计学处理表明，有淋巴结转移组间质多的（积分３－５分）仅占３２．５％，无淋巴结转移的占９０．４％，两者差别显著（Ｐ＜０．０１）。说明肺癌间质对其淋巴结转移有阻挡作用。从随访资料看，死亡组及存活远处转移组的积分明显低于存活组无转移病?
Objective: To investigate the relationship between peripheral lung cancer metastasis, metastasis, prognosis and CT appearance. Materials and Methods: The ratio of mesenchymal to mesenchymal in 87 cases of lung cancer was determined using Grocot’s hexamine silver staining method, and compared with CT findings, metastasis, and prognosis. RESULTS: Squamous cell carcinoma was more interstitial than adenocarcinoma, and the ratio of stroma components was not directly related to tumor size. Although there were lobulated cases in our observations, the distribution of tumor mass and interstitial mass in tumors was very uneven, but there was no significant difference between the scores of patients with or without leaf lobes (P>0.05). . There was no significant difference in the percentage of interstitial matter between the different tumor-lung interfaces except for the burr sign. There was also no significant correlation between the pleural recession sign and the collagen composition of the tumor interstitium. Although the degree of enhancement was different, the proportion of interstitial substance was slightly different, which not only enhanced the obvious interstitial components, but also slightly increased the interstitial components. However, statistical analysis showed that there was no significant difference between the two groups (P>0.05). The correlation with the microvessel density of lung cancer showed no significant correlation (average MVD of 1-2 points for argyrophil stains was 50.13±14.56, and mean MVD for points 3-5 was 53.67±12.71). This shows that there is no significant correlation between the degree of lung cancer enhancement and the interstitial substance. Statistical analysis showed that in the patients with lymph node metastasis, there were many interstitials (3-5 points) accounting for only 32.5%, and those without lymphatic metastasis accounted for 90.4%. There was a significant difference between the two groups (P<0.01). The lung cancer mesenchyme blocked the lymph node metastasis. From the follow-up data, the scores in the death group and the distant metastasis group were significantly lower than those in the survival group.